Article
The rs11705701 G>A polymorphism of IGF2BP2 is associated with IGF2BP2 mRNA and protein levels in the visceral adipose tissue - a link to type 2 diabetes susceptibility.
The review of diabetic studies : RDS - 1 Jan 2000
Chistiakov Dimitry A, Nikitin Alexey G, Smetanina Svetlana A, Bel'chikova Larisa N, Suplotova Lyudmila A, Shestakova Marina V, Nosikov Valery V
Abstract excerpt
BACKGROUND: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) regulates translation of IGF2, a growth factor that plays a key role in controlling fetal growth and organogenesis including adipogenesis and pancreatic development. In Caucasians, the rs4402960 G>T polymorphism of IGF2BP2 has been shown to predispose to type 2 diabetes (T2D) in multiple populations. In this study, we tested whether...
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