Article
A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
Diabetes - 1 Nov 2017
Mercader Josep M, Liao Rachel G, Bell Avery D, Dymek Zachary, Estrada Karol, Tukiainen Taru, Huerta-Chagoya Alicia, Moreno-Macías Hortensia, Jablonski Kathleen A, Hanson Robert L, Walford Geoffrey A, Moran Ignasi, Chen Ling, Agarwala Vineeta, Ordoñez-Sánchez María Luisa, Rodríguez-Guillen Rosario, Rodríguez-Torres Maribel, Segura-Kato Yayoi, García-Ortiz Humberto, Centeno-Cruz Federico, Barajas-Olmos Francisco, Caulkins Lizz, Puppala Sobha, Fontanillas Pierre, Williams Amy L, Bonàs-Guarch Sílvia, Hartl Chris, Ripke Stephan, Tooley Katherine, Lane Jacqueline, Zerrweck Carlos, Martínez-Hernández Angélica, Córdova Emilio J, Mendoza-Caamal Elvia, Contreras-Cubas Cecilia, González-Villalpando María E, Cruz-Bautista Ivette, Muñoz-Hernández Liliana, Gómez-Velasco Donaji, Alvirde Ulises, Henderson Brian E, Wilkens Lynne R, Le Marchand Loic, Arellano-Campos Olimpia, Riba Laura, Harden Maegan, Gabriel Stacey, Abboud Hanna E, Cortes Maria L, Revilla-Monsalve Cristina, Islas-Andrade Sergio, Soberon Xavier, Curran Joanne E, Jenkinson Christopher P, DeFronzo Ralph A, Lehman Donna M, Hanis Craig L, Bell Graeme I, Boehnke Michael, Blangero John, Duggirala Ravindranath, Saxena Richa, MacArthur Daniel, Ferrer Jorge, McCarroll Steven A, Torrents David, Knowler William C, Baier Leslie J, Burtt Noel, González-Villalpando Clicerio, Haiman Christopher A, Aguilar-Salinas Carlos A, Tusié-Luna Teresa, Flannick Jason, Jacobs Suzanne B R, Orozco Lorena, Altshuler David, Florez Jose C
Abstract excerpt
Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated genome-wide protein coding variation in a total of 8,227 individuals with T2D and 12,966 individuals without T2D of Latino descent. We identified a novel genetic...
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