Article
Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans.
Diabetes - 1 May 2007
Watanabe Richard M, Allayee Hooman, Xiang Anny H, Trigo Enrique, Hartiala Jaana, Lawrence Jean M, Buchanan Thomas A
Abstract excerpt
OBJECTIVE: Variation in transcription factor 7-like 2 (TCF7L2) gene has been shown to be associated with type 2 diabetes and diabetes-related quantitative traits. We examined variation in a 0.1-Mb region surrounding marker DG10S478 for association with diabetes-related quantitative traits in 132 Mexican-American families of a proband with previous gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:...
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