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Tenascin-C Is a Novel RBPJκ-Induced Target Gene for Notch Signaling in Gliomas

15 Jan 2009

Abstract excerpt

Tenascin-C (TNC) expression is known to correlate with malignancy in glioblastoma (GBM), a highly invasive and aggressive brain tumor that shows limited response to conventional therapies. In these malignant gliomas as well as in GBM cell lines, we found Notch2 protein to be strongly expressed. In a GBM tumor tissue microarray, RBPJk protein, a Notch2 cofactor for transcription, was found to be significantly...

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PMID: 19147558
DOI: 10.1158/0008-5472.can-08-2610

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