Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biologically Active TNIIIA2 Region in Tenascin-C Molecule: A Major Contributor to Elicit Aggressive Malignant Phenotypes From Tumors/Tumor Stroma.

Frontiers in immunology - 1 Jan 2020

Iyoda Takuya, Fujita Motomichi, Fukai Fumio

Abstract excerpt

Tenascin (TN)-C is highly expressed specifically in the lesions of inflammation-related diseases, including tumors. The expression level of TN-C in tumors and the tumor stroma is positively correlated with poor prognosis. However, no drugs targeting TN-C are currently clinically available, partly because the role of TN-C in tumor progression remains controversial. TN-C harbors an alternative splicing site in its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Fibronectins
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Domains and Motifs

Share to Stromal Cells

Share to Tenascin

Share to Tumor-Associated Macrophages

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 33362799
DOI: 10.3389/fimmu.2020.610096
PMCID: PMC7755593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biologically Active TNIIIA2 Region in Tenascin-C Molecule: A Major Contributor to Elicit Aggressive Malignant Phenotypes From Tumors/Tumor Stroma.PMID 33362799Read ↗

Biology of Tenascin C and its Role in Physiology and PathologySemantic proximity Read ↗

Revisiting the Tenascins: Exploitable as Cancer Targets?Semantic proximity Read ↗

Advances on the roles of tenascin-C in cancerSemantic proximity Read ↗

Tenascin C in metastasis: A view from the invasive frontSemantic proximity Read ↗

Shaping Up the Tumor Microenvironment With Cellular FibronectinSemantic proximity Read ↗

Tenascin-C at a glanceSemantic proximity Read ↗

Identification of established and novel extracellular matrix components in glioblastoma as targets for angiogenesis and prognosisSemantic proximity Read ↗

Internal Affairs: Tenascin-C as a Clinically Relevant, Endogenous Driver of Innate ImmunitySemantic proximity Read ↗

Targeting legumain-mediated cell-cell interaction sensitizes glioblastoma to immunotherapy in preclinical modelsSemantic proximity Read ↗

Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vesselsSemantic proximity Read ↗

Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growthSemantic proximity Read ↗

Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.