Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating Cells

17 Apr 2017

Abstract excerpt

Abstract Oncogenic signaling by NOTCH is elevated in brain tumor-initiating cells (BTIC) in malignant glioma, but the mechanism of its activation is unknown. Here we provide evidence that tenascin-C (TNC), an extracellular matrix protein prominent in malignant glioma, increases NOTCH activity in BTIC to promote their growth. We demonstrate the proximal localization of TNC and BTIC in human glioblastoma specimens...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cell Adhesion Molecules Research
Share to Cellular Mechanics and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28416488
DOI: 10.1158/0008-5472.can-16-2171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating CellsPMID 28416488Read ↗

ADAM-9 is a novel mediator of tenascin-C-stimulated invasiveness of brain tumor–initiating cellsSemantic proximity Read ↗

Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vesselsSemantic proximity Read ↗

Revisiting the Tenascins: Exploitable as Cancer Targets?Semantic proximity Read ↗

Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypesSemantic proximity Read ↗

CRTAC1-A reprograms extracellular matrix viscoelasticity to constrain glioma progressionSemantic proximity Read ↗

Advances on the roles of tenascin-C in cancerSemantic proximity Read ↗

Biologically Active TNIIIA2 Region in Tenascin-C Molecule: A Major Contributor to Elicit Aggressive Malignant Phenotypes From Tumors/Tumor Stroma.Semantic proximity Read ↗

Tenascin C in metastasis: A view from the invasive frontSemantic proximity Read ↗

Biology of Tenascin C and its Role in Physiology and PathologySemantic proximity Read ↗

Tenascin-C Is a Novel RBPJκ-Induced Target Gene for Notch Signaling in GliomasSemantic proximity Read ↗

Advances in tenascin-C biologySemantic proximity Read ↗

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.