Article
The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma.
Oncogene - 18 Nov 2010
Bralten L B C, Gravendeel A M, Kloosterhof N K, Sacchetti A, Vrijenhoek T, Veltman J A, van den Bent M J, Kros J M, Hoogenraad C C, Sillevis Smitt P A E, French P J
Abstract excerpt
Genomic translocations have been implicated in cancer. In this study, we performed a screen for genetic translocations in gliomas based on exon-level expression profiles. We identified a translocation in the contactin-associated protein-like 2 (CASPR2) gene, encoding a cell adhesion molecule. CASPR2 mRNA was fused to an expressed sequence tag that likely is part of the nuclear receptor coactivator 1 gene. Despite...
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