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Article

HER-2/neu-mediated Down-regulation of Biglycan Associated with Altered Growth Properties

12 May 2012

Abstract excerpt

The extracellular matrix protein biglycan (Bgn) is a leucine-rich proteoglycan that is involved in the matrix assembly, cellular migration and adhesion, cell growth, and apoptosis. Although a distinct expression of Bgn was found in a number of human tumors, the role of this protein in the initiation and/or maintenance of neoplastic transformation has not been studied in detail. Using an in vitro model of...

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PMID: 22582394
DOI: 10.1074/jbc.m111.334425

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