Article
Loss of collapsin response mediator Protein1, as detected by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EGFRvIII.
Cancer research - 15 Nov 2009
Mukherjee Joydeep, DeSouza Leroi V, Micallef Johann, Karim Zia, Croul Sid, Siu K W Michael, Guha Abhijit
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common and lethal primary human brain tumor. GBMs are characterized by a variety of genetic alterations, among which oncogenic mutations of epidermal growth factor receptor (EGFRvIII) is most common. GBMs harboring EGFRvIII have increased proliferation and invasive characteristics versus those expressing wild-type (wt) EGFR. To identify the molecular basis of this...
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