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Article

Abnormal network activity in a targeted genetic model of human double cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Jan 2009

Ackman James B, Aniksztejn Laurent, Crépel Valérie, Becq Hélène, Pellegrino Christophe, Cardoso Carlos, Ben-Ari Yehezkel, Represa Alfonso

Abstract excerpt

In human patients, cortical dysplasia produced by Doublecortin (DCX) mutations lead to mental retardation and intractable infantile epilepsies, but the underlying mechanisms are not known. DCX(-/-) mice have been generated to investigate this issue. However, they display no neocortical abnormality, lessening their impact on the field. In contrast, in utero knockdown of DCX RNA produces a morphologically relevant...

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Source

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Identifiers

PMID: 19144832
DOI: 10.1523/JNEUROSCI.4093-08.2009
PMCID: PMC6664957

Genes

DCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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