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Article

Spontaneous Epileptic Manifestations in a DCX Knockdown Model of Human Double Cortex

17 Feb 2010

Abstract excerpt

Previous reports indicate that in utero knockdown of doublecortin (DCX) results in the genesis of a subcortical heterotopia reminiscent of the doublecortex observed in female patients with DCX mutations. It has also been shown that these rats display an increased susceptibility to convulsant agents and increased cortical neurons excitability; but it is presently unknown whether they display spontaneous seizures....

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PMID: 20164125
DOI: 10.1093/cercor/bhq014

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