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Article

Magnetic resonance imaging and histological studies of corpus callosal and hippocampal abnormalities linked to doublecortin deficiency.

The Journal of comparative neurology - 10 Jan 2007

Kappeler Caroline, Dhenain Marc, Phan Dinh Tuy Françoise, Saillour Yoann, Marty Serge, Fallet-Bianco Catherine, Souville Isabelle, Souil Evelyne, Pinard Jean-Marc, Meyer Gundela, Encha-Razavi Ferechté, Volk Andreas, Beldjord Cherif, Chelly Jamel, Francis Fiona

Abstract excerpt

Mutated doublecortin (DCX) gives rise to severe abnormalities in human cortical development. Adult Dcx knockout mice show no major neocortical defects but do have a disorganized hippocampus. We report here the developmental basis of these hippocampal abnormalities. A heterotopic band of neurons was identified starting at E17.5 in the CA3 region and progressing throughout the CA1 region by E18.5. At neonatal...

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Source

Identifiers

PMID: 17111359
DOI: 10.1002/cne.21170

Genes

DCX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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