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Article

A Genetic Animal Model of Human Neocortical Heterotopia Associated with Seizures

15 Aug 1997

Abstract excerpt

Malformations of the human neocortex are commonly associated with developmental delays, mental retardation, and epilepsy. This study describes a novel neurologically mutant rat exhibiting a forebrain anomaly resembling the human neuronal migration disorder of double cortex. This mutant displays a telencephalic internal structural heterotopia (tish) that is inherited in an autosomal recessive manner. The bilateral...

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PMID: 9236234
DOI: 10.1523/jneurosci.17-16-06236.1997

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