Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Minor and clinically non-significant interaction between toloxatone and amitriptyline.

European journal of clinical pharmacology - 1 Jan 1993

Vandel S, Bertschy G, Perault M C, Sandoz M, Bouquet S, Chakroun R, Guibert S, Vandel B

Abstract excerpt

The possibility of a pharmacokinetic interaction between amitriptyline and toloxatone (a new MAOI-A) has been studied in 17 depressed in-patients. Amitriptyline and its demethylated and hydroxylated metabolites in blood and urine were measured at steady state after the administration of amitriptyline with and without toloxatone in steady state. The metabolic status of patients was determined using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Depression
Share to Drug Interactions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Therapy, Combination

Share to Oxazoles

Share to Phenotype

Share to Reproducibility of Results

Source

Identifiers

PMID: 8436164
DOI: 10.1007/BF00315289

Genes

AMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Minor and clinically non-significant interaction between toloxatone and amitriptyline.PMID 8436164Read ↗

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.Semantic proximity Read ↗

Debrisoquine and dextromethorphan phenotyping and antidepressant treatment.Semantic proximity Read ↗

Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wild-type allele--a slowly reversible interaction with fluoxetine.Semantic proximity Read ↗

Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients.Semantic proximity Read ↗

Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study.Semantic proximity Read ↗

Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies.Semantic proximity Read ↗

Correlation of inter-individual variations of amitriptyline metabolism examined in hairs with CYP2C19 and CYP2D6 polymorphisms.Semantic proximity Read ↗

Lack of pharmacokinetic interaction between dextromethorphan, coumarin and mephenytoin in man after simultaneous administration.Semantic proximity Read ↗

Increased trimipramine plasma levels during fluvoxamine comedication.Semantic proximity Read ↗

Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline.Semantic proximity Read ↗

Influence of amiodarone on genetically determined drug metabolism in humans.Semantic proximity Read ↗

Just Say No to Postmortem Drug Dose CalculationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.