Article
Minor and clinically non-significant interaction between toloxatone and amitriptyline.
European journal of clinical pharmacology - 1 Jan 1993
Vandel S, Bertschy G, Perault M C, Sandoz M, Bouquet S, Chakroun R, Guibert S, Vandel B
Abstract excerpt
The possibility of a pharmacokinetic interaction between amitriptyline and toloxatone (a new MAOI-A) has been studied in 17 depressed in-patients. Amitriptyline and its demethylated and hydroxylated metabolites in blood and urine were measured at steady state after the administration of amitripty...
Topics
- Adult
- Aged
- Amitriptyline
- Depression
- Drug Interactions
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Monoamine Oxidase Inhibitors
- Oxazoles
- Oxazolidinones
- Phenotype
- Reproducibility of Results