Article
Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone.
Clinical pharmacology and therapeutics - 1 Mar 1994
Funck-Brentano C, Becquemont L, Kroemer H K, Bühl K, Knebel N G, Eichelbaum M, Jaillon P
Abstract excerpt
We studied the influence of cytochrome P450 2D6 (CYP2D6) on the steady-state disposition kinetics and the electrocardiographic effects of flecainide at two doses and during combination with amiodarone. Seven extensive and five poor metabolizers of dextromethorphan were studied during a three-peri...
Topics
- Administration, Oral
- Adult
- Amiodarone
- Analysis of Variance
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Interactions
- Electrocardiography
- Flecainide
- Genetic Variation
- Humans