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Article

Genetically determined steady-state interaction between encainide and quinidine in patients with arrhythmias.

The Journal of pharmacology and experimental therapeutics - 1 Nov 1990

Turgeon J, Pavlou H N, Wong W, Funck-Brentano C, Roden D M

Abstract excerpt

A genetically determined pharmacokinetic and pharmacodynamic interaction between quinidine and single doses of encainide in healthy volunteers has previously been described. In subjects with the extensive metabolizer phenotype, quinidine blunted encainide-induced QRS prolongation (a marker of sodium channel block) because it impaired encainide biotransformation to the potent active metabolites O-desmethyl...

Topics

Aged
Anilides
Arrhythmias, Cardiac
Dealkylation
Drug Interactions
Electrocardiography
Encainide
Female
Genetics
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Quinidine

Source

Identifiers

PMID: 2123007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2123007-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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