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Article

Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2006

Kumar Vikas, Locuson Chuck W, Sham Yuk Y, Tracy Timothy S

Abstract excerpt

CYP2C9 substrates can exhibit both hyperbolic and atypical kinetic profiles, and their metabolism can be activated or inhibited depending on the effector studied. CYP2C9 genetic variants can also affect both substrate turnover and kinetic profile. The present study assessed whether analogs of the effector amiodarone differentially altered the atypical kinetic profile of the substrate naproxen and whether this...

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Identifiers

PMID: 16815961
DOI: 10.1124/dmd.106.010678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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