Article
Effect of amiodarone on the plasma levels of metoprolol.
The American journal of cardiology - 15 Nov 2004
Werner Dierk, Wuttke Henrike, Fromm Martin F, Schaefer Simon, Eschenhagen Thomas, Brune Kay, Daniel Werner G, Werner Ulrike
Abstract excerpt
On average, metoprolol plasma concentration is doubled after an amiodarone loading dose (1.2 g/day over a period of 6 days). However, the individual amount of this drug interaction depends on the CYP2D6 genotype.
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