Article
Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism.
The Journal of nutrition - 1 Mar 2009
Saracino Misty R, Bigler Jeannette, Schwarz Yvonne, Chang Jyh-Lurn, Li Shiuying, Li Lin, White Emily, Potter John D, Lampe Johanna W
Abstract excerpt
UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates bilirubin, estrogens, and xenobiotic compounds. The UGT1A1*28 polymorphism results in lower promoter activity due to 7 thymine-adenine (TA) repeats rather than the more common 6 TA repeats. Previously, we showed that serum bilirubin, a marker of UGT1A1 activity, was lower among individuals homozygous for the UGT1A1*28 polymorphism (7/7) when randomized to a...
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