Article
Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study.
Circulation - 3 Oct 2006
Lin Jing-Ping, O'Donnell Christopher J, Schwaiger Johannes P, Cupples L Adrienne, Lingenhel Arno, Hunt Steven C, Yang Song, Kronenberg Florian
Abstract excerpt
BACKGROUND: Bilirubin is an antioxidant that suppresses lipid oxidation and retards atherosclerosis formation. An inverse association between serum bilirubin and coronary heart disease has been reported. Linkage studies have identified a major locus at the chromosome 2q telomere that affects bilirubin concentrations. A candidate gene in the linkage region encodes hepatic bilirubin uridine...
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