Article
UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2011
Navarro Sandi L, Chen Yu, Li Lin, Li Shuying S, Chang Jyh-Lurn, Schwarz Yvonne, King Irena B, Potter John D, Bigler Jeannette, Lampe Johanna W
Abstract excerpt
Acetaminophen (APAP) glucuronidation is thought to occur mainly by UDP-glucuronosyltransferases (UGT) in the UGT1A family. Interindividual variation in APAP glucuronidation is attributed in part to polymorphisms in UGT1As. However, evidence suggests that UGT2B15 may also be important. We evaluated, in a controlled feeding trial, whether APAP conjugation differed by UGT1A6 and UGT2B15 genotypes and whether...
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