Article
UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial.
The Journal of nutrition - 1 Apr 2007
Chang Jyh-Lurn, Bigler Jeannette, Schwarz Yvonne, Li Shuying S, Li Lin, King Irena B, Potter John D, Lampe Johanna W
Abstract excerpt
UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates bilirubin, estrogens, and exogenous compounds, including dietary carcinogens. The UGT1A1*28 polymorphism, characterized by variation in the number of thymine-adenine repeats in the promoter region, modulates UGT1A1 transcription. Observational and in vitro studies suggest that certain phytochemicals may increase UGT activity. We investigated, in a randomized,...
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