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Article

A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease.

Journal of Crohn's & colitis - 1 Jun 2012

de Vries Hilbert S, Te Morsche Rene H M, Jenniskens Kevin, Peters Wilbert H M, de Jong Dirk J

Abstract excerpt

BACKGROUND: An imbalance between the production of reactive oxygen species (ROS) and their capturing by antioxidants results in oxidative stress, this may play an important role in the pathogenesis of inflammatory bowel disease (IBD). Since bilirubin is an important endogenous antioxidant, increased levels of bilirubin may protect against IBD. UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved...

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PMID: 22398043
DOI: 10.1016/j.crohns.2011.11.010

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