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Article

polo encodes a protein kinase homolog required for mitosis in Drosophila.

Genes & development - 1 Dec 1991

Llamazares S, Moreira A, Tavares A, Girdham C, Spruce B A, Gonzalez C, Karess R E, Glover D M, Sunkel C E

Abstract excerpt

We show that mutation in polo leads to a variety of abnormal mitoses in Drosophila larval neuroblasts. These include otherwise normal looking mitotic spindles upon which chromosomes appear overcondensed; normal bipolar spindles with polyploid complements of chromosomes; bipolar spindles in which one pole can be unusually broad; and monopolar spindles. We have cloned the polo gene from a mutant allele carrying a...

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Identifiers

PMID: 1660828
DOI: 10.1101/gad.5.12a.2153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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polo encodes a protein kinase homolog required for mitosis in Drosophila.PMID 1660828Read ↗

Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles.Semantic proximity Read ↗

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Metaphase arrest with centromere separation in polo mutants of Drosophila.Semantic proximity Read ↗

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.Semantic proximity Read ↗

The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes.Semantic proximity Read ↗

Polo-like kinase-activating kinasesSemantic proximity Read ↗

Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures.Semantic proximity Read ↗

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Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.Semantic proximity Read ↗

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.Semantic proximity Read ↗

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