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Article

Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development.

Genetics - 1 Aug 1998

Secombe J, Pispa J, Saint R, Richardson H

Abstract excerpt

We have generated and characterized a Drosophila cyclin E hypomorphic mutation, DmcycEJP, that is homozygous viable and fertile, but results in adults with rough eyes. The mutation arose from an internal deletion of an existing P[w+lacZ] element inserted 14 kb upstream of the transcription start site of the DmcycE zygotic mRNA. The presence of this deleted P element, but not the P[w+lacZ] element from which it...

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Identifiers

PMID: 9691043
DOI: 10.1093/genetics/149.4.1867
PMCID: PMC1460270

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