Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development.

doi:10.1093/genetics/149.4.1867

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Article

Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development.

Genetics - 1 Aug 1998

Secombe J, Pispa J, Saint R, Richardson H

Abstract excerpt

We have generated and characterized a Drosophila cyclin E hypomorphic mutation, DmcycEJP, that is homozygous viable and fertile, but results in adults with rough eyes. The mutation arose from an internal deletion of an existing P[w+lacZ] element inserted 14 kb upstream of the transcription start...

Topics

Alleles
Animals
Cell Cycle
Cell Division
Cyclin E
Drosophila melanogaster
Eye Abnormalities
Female
Genes, Insect
Male
Microscopy, Electron, Scanning
Mutation
Phenotype
S Phase

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