Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the pelota gene causes early embryonic lethality and defects in cell cycle progression.

Molecular and cellular biology - 1 Feb 2003

Adham Ibrahim M, Sallam Mahmoud A, Steding Gerd, Korabiowska Monika, Brinck Ulrich, Hoyer-Fender Sigrid, Oh Changkyu, Engel Wolfgang

Abstract excerpt

Mutations in either the Drosophila melanogaster pelota or pelo gene or the Saccharomyces cerevisiae homologous gene, DOM34, cause defects of spermatogenesis and oogenesis in Drosophila, and delay of growth and failure of sporulation in yeast. These phenotypes suggest that pelota is required for normal progression of the mitotic and meiotic cell cycle. To determine the role of the pelota in mouse development and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Death

Share to Genetic Engineering

Share to Mice, Mutant Strains

Share to Mitosis

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 12556505
DOI: 10.1128/MCB.23.4.1470-1476.2003
PMCID: PMC141158

Genes

PELO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the pelota gene causes early embryonic lethality and defects in cell cycle progression.PMID 12556505Read ↗

no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila.Semantic proximity Read ↗

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potentialSemantic proximity Read ↗

Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway.Semantic proximity Read ↗

Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis.Semantic proximity Read ↗

Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase.Semantic proximity Read ↗

A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis.Semantic proximity Read ↗

Mouse models of aneuploidy to understand chromosome disordersSemantic proximity Read ↗

Distinct requirements for Pho, Sfmbt, and Ino80 for cell survival in Drosophila.Semantic proximity Read ↗

Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.Semantic proximity Read ↗

Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes.Semantic proximity Read ↗

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.Semantic proximity Read ↗

Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.