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Article

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer.

Cancer letters - 18 Apr 2007

Stevens Richard G, Swede Helen, Heinen Christopher D, Jablonski Melissa, Grupka Michael, Ross Barry, Parente Melissa, Tirnauer Jennifer S, Giardina Charles, Rajan Thiruchandurai V, Rosenberg Daniel W, Levine Joel

Abstract excerpt

Early detection is crucial in the prevention of colorectal cancer (CRC) deaths. The earliest detectable neoplastic lesion in the colon is the aberrant crypt foci (ACF). A major question is whether ACF are precursors of CRC, and thus, early biomarkers for CRC risk. If so, we hypothesized that the number of ACF would be higher in patients who had a family history of CRC compared to patients without. We counted ACF...

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Identifiers

PMID: 16950561
DOI: 10.1016/j.canlet.2006.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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