Article
Lack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population.
Brain research - 21 Oct 2010
Wu Zhong-Chen, Yu Jin-Tai, Wang Nai-Dong, Yu Nan-Nan, Zhang Qun, Chen Wei, Zhang Wei, Zhu Qi-Xiu, Tan Lan
Abstract excerpt
Protocadherin 11X (Pcdh11X) has been suspected to be associated with Alzheimer's disease through participating in the metabolism of PP1α and β-catenin or by altering the synaptic functions. A recent genome-wide association study reported that a common single nucleotide polymorphism (SNP, rs5984894) in the gene encoding Pcdh11X was associated with susceptibility to late-onset Alzheimer's disease (LOAD) in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.