Article
Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Lescai Francesco, Pirazzini Chiara, D'Agostino Giuseppe, Santoro Aurelia, Ghidoni Roberta, Benussi Luisa, Galimberti Daniela, Federica Esposito, Marchegiani Francesca, Cardelli Maurizio, Olivieri Fabiola, Nacmias Benedetta, Sorbi Sandro, Bagnoli Silvia, Tagliavini Fabrizio, Albani Diego, Martinelli Boneschi Filippo, Binetti Giuliano, Forloni Gianluigi, Quadri Pierluigi, Scarpini Elio, Franceschi Claudio
Abstract excerpt
A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for...
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