Article
Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.
Brain research - 6 Apr 2011
Miar Ana, Alvarez Victoria, Corao Ana I, Alonso Belén, Díaz Marta, Menéndez Manuel, Martínez Carmen, Calatayud Maite, Morís Germán, Coto Eliecer
Abstract excerpt
A recent genome-wide association study (GWA) reported a significant association between single nucleotide polymorphisms (SNPs) at the PCDH11X gene and late-onset Alzheimer's disease (LOAD). Our research was designated to replicate this association, including non previously analyzed PCDH11X and PCDH11Y SNPs. We genotyped four PCDH11X and one PCDH11Y SNPs in a total of 420 LOAD patients and 350 healthy controls...
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