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Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia

1 Jan 2018

Abstract excerpt

Na+/H+ exchangers (NHEs) represent a highly conserved family of ion transporters that regulate pH homeostasis. NHEs as well as other proton transporters were previously linked to the regulation of the Wnt signaling pathway, cell polarity signaling, and mucociliary function. Furthermore, mutations in the gene SLC9A3 (encoding NHE3) were detected as additional risk factors for airway infections in cystic fibrosis...

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PMID: 30300884
DOI: 10.1159/000492973

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