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Article

Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species.

American journal of physiology. Renal physiology - 1 Jun 2004

Chen Lan, Fuller Catherine M, Kleyman Thomas R, Matalon Sadis

Abstract excerpt

We studied the effects of two mutations of the extracellular loop of the alpha-subunit of the (ENaC) on amiloride-sensitive current in Xenopus laevis oocytes and the inhibition of this current by 3-morpholinosydnonimine (SIN-1). Injection of oocytes with wild-type (wt) alpha-,beta-,gamma-rENaC cR...

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Identifiers

PMID: 14969999
DOI: 10.1152/ajprenal.00352.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14969999-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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