Article
Cloning and functional studies of splice variants of the alpha-subunit of the amiloride-sensitive Na+ channel.
The American journal of physiology - 1 Apr 1998
Tucker J K, Tamba K, Lee Y J, Shen L L, Warnock D G, Oh Y
Abstract excerpt
The alpha-subunit of the amiloride-sensitive epithelial Na+ channel (alpha ENaC) is critical in forming an ion conductive pore in the membrane. We have identified the wild-type and three splice variants of the human alpha ENaC (h alpha ENaC) from the human lung cell line H441, using RT-PCR. These splice variants contain various structures in the extracellular domain, resulting in premature truncation (h alpha...
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