Article
Cloning and functional studies of splice variants of the alpha-subunit of the amiloride-sensitive Na+ channel.
The American journal of physiology - 1 Apr 1998
Tucker J K, Tamba K, Lee Y J, Shen L L, Warnock D G, Oh Y
Abstract excerpt
The alpha-subunit of the amiloride-sensitive epithelial Na+ channel (alpha ENaC) is critical in forming an ion conductive pore in the membrane. We have identified the wild-type and three splice variants of the human alpha ENaC (h alpha ENaC) from the human lung cell line H441, using RT-PCR. These...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA, Recombinant
- Epithelial Sodium Channels
- Exons
- Female
- Genetic Variation
- Humans
- Introns
- Molecular Sequence Data
- Oocytes
- Sodium Channels
- Xenopus laevis