Article
The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis.
Annals of internal medicine - 15 Aug 2006
Uitterlinden André G, Ralston Stuart H, Brandi Maria Luisa, Carey Alisoun H, Grinberg Daniel, Langdahl Bente L, Lips Paul, Lorenc Roman, Obermayer-Pietsch Barbara, Reeve Jonathan, Reid David M, Amedei Antonietta, Amidei Antonietta, Bassiti Amelia, Bustamante Mariona, Husted Lise Bjerre, Diez-Perez Adolfo, Dobnig Harald, Dunning Alison M, Enjuanes Anna, Fahrleitner-Pammer Astrid, Fang Yue, Karczmarewicz Elzbieta, Kruk Marcin, van Leeuwen Johannes P T M, Mavilia Carmelo, van Meurs Joyce B J, Mangion Jon, McGuigan Fiona E A, Pols Huibert A P, Renner Wilfried, Rivadeneira Fernando, van Schoor Natasja M, Scollen Serena, Sherlock Rachael E, Ioannidis John P A
Abstract excerpt
BACKGROUND: Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear. OBJECTIVE: To evaluate the relation between VDR polymorphisms, BMD, and fractures. DESIGN: Prospective multicenter large-scale association study. SETTING: The Genetic Markers for Osteoporosis consortium,...
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