Article
Association between genetic variants of the leukotriene biosynthesis pathway and the risk of stroke: a case-control study in the Chinese Han population.
Chinese medical journal - 1 Jan 2013
Sun Hao, Zhang Jing, Wang Jun, Sun Tao, Xiao Hang, Zhang Jin-Song
Abstract excerpt
BACKGROUND: Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties. Leukotriene-based inflammation has been demonstrated to play a crucial role in atherosclerosis, a major risk factor for several human diseases. Recently, human genetic studies from us and others suggest that single nucleotide polymorphisms (SNPs) in leukotriene pathway genes influence the risk of...
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