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Article

Genetic contribution of the leukotriene pathway to coronary artery disease.

Human genetics - 1 Jun 2011

Hartiala Jaana, Li Dalin, Conti David V, Vikman Susanna, Patel Yesha, Tang W H Wilson, Brennan Marie-Louise, Newman John W, Stephensen Charles B, Armstrong Patrice, Hazen Stanley L, Allayee Hooman

Abstract excerpt

We evaluated the genetic contribution of the leukotriene (LT) pathway to risk of coronary artery disease (CAD) in 4,512 Caucasian and African American subjects ascertained through elective cardiac evaluation. Of the three previously associated variants, the shorter "3" and "4" alleles of a promoter repeat polymorphism in ALOX5 increased risk of CAD in African Americans (OR = 1.4, 95% CI 1.0-1.9; p = 0.04),...

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Source

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Identifiers

PMID: 21293878
DOI: 10.1007/s00439-011-0963-3
PMCID: PMC3092945

Genes

CAD
LTB
ALOX5

Provenance

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