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Article

Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Jun 2015

Merhi Mahmoud, Demirdjian Sally, Hariri Essa, Sabbah Nada, Youhanna Sonia, Ghassibe-Sabbagh Michella, Naoum Joseph, Haber Marc, Othman Raed, Kibbani Samer, Chammas Elie, Kanbar Roy, Bayeh Hamid El, Chami Youssef, Abchee Antoine, Platt Daniel E, Zalloua Pierre, Khazen Georges

Abstract excerpt

BACKGROUND: The role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synthesis essential in atherosclerosis pathogenesis. AIM: The aim of this study is to investigate the effect of "selected" genetic variants within the leukotriene (LT) pathway and other variants on...

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Source

Identifiers

PMID: 25902778
DOI: 10.1007/s00011-015-0821-1

Genes

CAD
PON1
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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