Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases.

doi:10.1016/j.autrev.2011.07.007

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Article

Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases.

Autoimmunity reviews - 1 Feb 2012

Anaya Juan-Manuel, Kim-Howard Xana, Prahalad Sampath, Cherñavsky Alejandra, Cañas Carlos, Rojas-Villarraga Adriana, Bohnsack John, Jonsson Roland, Bolstad Anne Isine, Brun Johan G, Cobb Beth, Moser Kathy L, James Judith A, Harley John B, Nath Swapan K

Abstract excerpt

Many autoimmune diseases (ADs) share similar underlying pathology and have a tendency to cluster within families, supporting the involvement of shared susceptibility genes. To date, most of the genetic variants associated with systemic lupus erythematosus (SLE) susceptibility also show association with others ADs. ITGAM and its associated 'predisposing' variant (rs1143679, Arg77His), predicted to alter the...

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PMID: 21840425
DOI: 10.1016/j.autrev.2011.07.007
PMCID: PMC3224188

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ITGAM

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Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases.PMID 21840425Read ↗

Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.Semantic proximity Read ↗

Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis.Semantic proximity Read ↗

ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients from a sample of the Polish population.Semantic proximity Read ↗

Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population.Semantic proximity Read ↗

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Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).Semantic proximity Read ↗

Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts.Semantic proximity Read ↗

ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.Semantic proximity Read ↗

ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico.Semantic proximity Read ↗

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.Semantic proximity Read ↗

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