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Article

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes.

Hepatology (Baltimore, Md.) - 1 Feb 2009

Vick Binje, Weber Achim, Urbanik Toni, Maass Thorsten, Teufel Andreas, Krammer Peter H, Opferman Joseph T, Schuchmann Marcus, Galle Peter R, Schulze-Bergkamen Henning

Abstract excerpt

UNLABELLED: Myeloid cell leukemia-1 (Mcl-1) is an antiapoptotic member of the Bcl-2 protein family. It interacts with proapoptotic Bcl-2 family members, thereby inhibiting mitochondrial activation and induction of apoptosis. Mcl-1 is essential for embryonal development and the maintenance of B cells, T cells, and hematopoietic stem cells. We have recently shown that induction of Mcl-1 by growth factors rescues...

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Identifiers

PMID: 19127517
DOI: 10.1002/hep.22664
PMCID: PMC2753874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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