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Article

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver.

Hepatology (Baltimore, Md.) - 1 Oct 2009

Hikita Hayato, Takehara Tetsuo, Shimizu Satoshi, Kodama Takahiro, Li Wei, Miyagi Takuya, Hosui Atsushi, Ishida Hisashi, Ohkawa Kazuyoshi, Kanto Tatsuya, Hiramatsu Naoki, Yin Xiao-Ming, Hennighausen Lothar, Tatsumi Tomohide, Hayashi Norio

Abstract excerpt

UNLABELLED: Anti-apoptotic members of the Bcl-2 family, including Bcl-2, Bcl-xL, Mcl-1, Bcl-w and Bfl-1, inhibit the mitochondrial pathway of apoptosis. Bcl-xL and Mcl-1 are constitutively expressed in the liver. Although previous research established Bcl-xL as a critical apoptosis antagonist in differentiated hepatocytes, the significance of Mcl-1 in the liver, especially in conjunction with Bcl-xL, has not been...

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Identifiers

PMID: 19676108
DOI: 10.1002/hep.23126
PMCID: PMC3560852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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