Liver Receptor Homolog-1 (LRH-1/NR5A2) orchestrates hepatic inflammation and TNF-induced cell death

Abstract excerpt

<h4>Summary</h4> Liver Receptor Homolog-1 (LRH-1/NR5A2) is a nuclear receptor that has been shown to promote apoptosis resistance in various tissues and disease contexts, however, its role in liver cell death remains unexplored. Deletion of LRH-1 in hepatocytes developed into a mild steatosis and inflammation already under steady-state conditions. Unexpectedly, hepatocyte-specific deletion of LRH-1 also resulted...

Topics

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• Carcinoma, Pancreatic Ductal
• Cell Cycle Checkpoints
• Drug Transport and Resistance Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Estrogen and related hormone effects
• interferon and immune responses
• Liver Disease Diagnosis and Treatment
• Peroxisome Proliferator-Activated Receptors

Identifiers and source

Literature Corpus work

f3692685-e92b-5ee4-8f67-b44d0d8f665f

DOI

10.1101/2023.05.24.542039