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Article

Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer.

Journal of cancer research and clinical oncology - 1 Aug 2009

Vallian Sadeq, Sedaghat Mandana, Nassiri Isar, Frazmand Ali

Abstract excerpt

INTRODUCTION: p16(INK4A) is a tumor suppressor encoding the Cdk inhibitor protein, which acts to repress Cdk4/6 and pRb phosphorylation. p16(INK4A) gene can be inactivated by a variety of events, including promoter hypermethylation. MATERIALS AND METHODS: To investigate the methylation status of the p16(INK4A) gene in Iranian patients with breast carcinoma, promoter methylation was studied by methylation-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19125298
DOI: 10.1007/s00432-008-0534-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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