Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promoter methylation and loss of <i>p16</i><sup><i>INK4a</i></sup> gene expression in head and neck cancer

22 Nov 2011

Abstract excerpt

BACKGROUND: Silencing of tumor suppressor genes plays a vital role in head and neck carcinogenesis. In this study we aimed to evaluate aberrant p16(INK4a) gene promoter methylation in patients with head and neck cancer. METHODS: Methylation of the gene was investigated by bisulfite modification/methylation-specific polymerase chain reaction and gene expression levels were analyzed by quantitative reverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Head and Neck Cancer Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22106032
DOI: 10.1002/hed.21949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter methylation and loss of <i>p16</i><sup><i>INK4a</i></sup> gene expression in head and neck cancerPMID 22106032Read ↗

Inactivation of p16INK4a in primary tumors and cell lines of head and neck squamous cell carcinoma.Semantic proximity Read ↗

<i>O</i> 6 <i>-Methylguanine-DNA Methyltransferase</i> Gene: Epigenetic Silencing and Prognostic Value in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Promoter methylation of <i>p16</i><sup><i>INK4a</i></sup>, <i>RASSF1A</i>, and <i>DAPK</i> is frequent in salivary adenoid cystic carcinomaSemantic proximity Read ↗

Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma.Semantic proximity Read ↗

Promoter Hypermethylation Profile of Tumour Suppressor Genes in Oral Leukoplakia and Oral Squamous Cell CarcinomaSemantic proximity Read ↗

Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinomaSemantic proximity Read ↗

p16(INK4a) promoter hypermethylation in oral scrapings of oral squamous cell carcinoma risk patients.Semantic proximity Read ↗

Tumor suppressor gene p16 (CDKN2A) mutation status and promoter inactivation in head and neck cancer.Semantic proximity Read ↗

p16INK4a and p15INK4b gene promoter methylation in cervical cancer patientsSemantic proximity Read ↗

p16INK4 is inactivated by extensive CpG methylation in human hepatocellular carcinomaSemantic proximity Read ↗

Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer.Semantic proximity Read ↗

Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.