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The methylation pattern of p16<sup>INK4a</sup>gene promoter in psoriatic epidermis and its clinical significance

29 Mar 2008

Abstract excerpt

BACKGROUND: Alteration of the p16INK4a gene by epigenetic changes has been described in some hyperproliferative skin diseases, but its importance in psoriasis has not yet been established. OBJECTIVES: To investigate the methylation status of the p16INK4a gene in psoriatic epidermis, its clinical significance and the possible epigenetic mechanisms of psoriasis. METHODS: DNA and RNA specimens were obtained from the...

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PMID: 18373711
DOI: 10.1111/j.1365-2133.2008.08505.x

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