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Article

p16INK4a and p15INK4b gene promoter methylation in cervical cancer patients

26 Mar 2012

Abstract excerpt

The aim of this study was to determine the methylation status of the p16(INK4a), p14(ARF) and p15(INK4b) genes and the subsequent effect of hypermethylation on the expression of these genes in cervical cancer patients. Methylation-specific PCR (MSP) was performed to analyse the methylation status of p16(INK4a), p14(ARF) and p15(INK4b) genes and was confirmed by sequencing. Reverse transcription PCR (RT-PCR) was...

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Share to Cancer-related gene regulation
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PMID: 22783444
DOI: 10.3892/ol.2012.655

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