Article
Alterations of the P16 gene in uterine cervical carcinoma from Indian patients.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000
Tripathi A, Banerjee S, Roy A, Roychowdhury S, Panda C K
Abstract excerpt
In our analysis, alterations in the P16 tumor suppressor gene were seen in 33% (15/46) of sampled uterine cervical lesions. Among the alterations, mutations in P16 were detected in 15% (7/46) of the samples. One mutation occurred at intron 1/exon 2 splice junction. All the other mutations were in exon 2 with three of them as silent mutations. The promoter hypermethylation and homozygous deletion of P16 gene were...
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