Article
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
PLoS genetics - 1 Jan 2009
Maier Lisa M, Lowe Christopher E, Cooper Jason, Downes Kate, Anderson David E, Severson Christopher, Clark Pamela M, Healy Brian, Walker Neil, Aubin Cristin, Oksenberg Jorge R, Hauser Stephen L, Compston Alistair, Sawcer Stephen, De Jager Philip L, Wicker Linda S, Todd John A, Hafler David A
Abstract excerpt
Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte Antigen (HLA) complex was the only known susceptibility locus for both T1D and MS, but loci outside the HLA complex harboring risk alleles have been discovered and fully replicated. A genome-wide association scan for...
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