Article
Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk.
Carcinogenesis - 1 Sept 2015
Sevilya Ziv, Leitner-Dagan Yael, Pinchev Mila, Kremer Ran, Elinger Dalia, Lejbkowicz Flavio, Rennert Hedy S, Freedman Laurence S, Rennert Gad, Paz-Elizur Tamar, Livneh Zvi
Abstract excerpt
The key role of DNA repair in removing DNA damage and minimizing mutations makes it an attractive target for cancer risk assessment and prevention. Here we describe the development of a robust assay for apurinic/apyrimidinic (AP) endonuclease 1 (APE1; APEX1), an essential enzyme involved in the repair of oxidative DNA damage. APE1 DNA repair enzymatic activity was measured in peripheral blood mononuclear cell...
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