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Article

Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk.

Carcinogenesis - 1 Aug 2004

Ito Hidemi, Matsuo Keitaro, Hamajima Nobuyuki, Mitsudomi Tetsuya, Sugiura Takahiko, Saito Toshiko, Yasue Tetsuo, Lee Kyoung-Mu, Kang Daehee, Yoo Keun-Young, Sato Shigeki, Ueda Ryuzo, Tajima Kazuo

Abstract excerpt

APE1 (apurinic/apyrimidinic endonuclease 1) and XRCC1 (X-ray cross-complementing group 1) are DNA repair proteins that play important roles in the base excision repair (BER) pathway. Polymorphisms in their encoding genes are associated with altered DNA repair capacity and thus may impact on cance...

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Identifiers

PMID: 15044328
DOI: 10.1093/carcin/bgh153

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15044328-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk.PMID 15044328Read ↗

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The influence of XRCC1 genetic variants on lung cancer susceptibility in Chinese Han population.Semantic proximity Read ↗

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