Article
Update on genetics in inflammatory disease.
Best practice & research. Clinical gastroenterology - 1 Jan 2009
Noomen Casper G, Hommes Daniel W, Fidder Herma H
Abstract excerpt
Crohn's disease and ulcerative colitis are chronic inflammatory disorders caused by a disruptive interaction between the immune system and gut luminal factors. Although the exact aetiology of IBD remains unclear, accumulating data, including genome-wide association studies (GWAS), have advanced our understanding of the immunopathogenesis. This review highlights the role in gut homeostasis and IBD pathogenesis. It...
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